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Measurement of Particle Size Distribution in Turbid Solutions by Dynamic Light Scattering Microscopy

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Published on: January 9, 2017

Calibration for a count rate-dependent time correlation function and a random noise reduction in pulsed dynamic light

Takashi Hiroi¹, Sadaki Samitsu², Hideaki Kano³

¹National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, Japan. HIROI.Takashi@nims.go.jp.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|March 14, 2022

Summary

A new pulsed dynamic light scattering (DLS) system was developed for enhanced particle size analysis. This system corrects for distortions and reduces noise, improving measurement accuracy for advanced applications.

Keywords:

Clipping effect Dynamics light scattering Noise reduction Photon correlation Pulsed laser Time gating

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Area of Science:

Photonics and Spectroscopy
Materials Science
Nanotechnology

Background:

Dynamic Light Scattering (DLS) is a widely used technique for determining particle size.
Traditional DLS systems can be limited by noise and measurement artifacts.
The development of pulsed DLS offers potential for advanced applications like nonlinear DLS.

Purpose of the Study:

To develop a pulsed dynamic light scattering (DLS) system for improved particle size analysis.
To address limitations in current DLS techniques, such as clipping effects and noise.
To enable potential applications in nonlinear DLS with molecular selectivity.

Main Methods:

Development of a pulsed DLS system integrating a sub-nanosecond pulsed laser and software-based detection.
Theoretical simulation for calibrating time correlation function distortions caused by clipping effects.
Implementation of time gating synchronized to laser pulses for noise reduction.

Main Results:

Successful calibration of the time correlation function, correcting for clipping effect-induced distortions.
Demonstrated effective removal of random noises using synchronized time gating.
The developed system accurately measures particle size, overcoming common DLS limitations.

Conclusions:

The novel pulsed DLS system provides accurate particle size measurements.
The calibration and noise reduction methods enhance the reliability of DLS analysis.
This technology paves the way for advanced DLS techniques, including nonlinear DLS.