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The Pandemic Response Box─Accelerating Drug Discovery Efforts after Disease Outbreaks.

Kirandeep Samby1, Dominique Besson1, Anirban Dutta2

  • 1Medicines for Malaria Venture, P.O. Box 1826, 20 Route de Pré-Bois, 1215 Geneva 15, Switzerland.

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|March 14, 2022
PubMed
Summary
This summary is machine-generated.

A new Pandemic Response Box of 400 compounds aids drug discovery for emerging infectious diseases. This freely available resource accelerates the development of targeted therapies beyond initial drug repurposing efforts.

Keywords:
Pandemicsantibacterialsantifungalsantiviralsdrug discoveryscreening

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Area of Science:

  • Pharmacology and Medicinal Chemistry
  • Infectious Disease Research
  • Drug Discovery and Development

Background:

  • The COVID-19 pandemic highlighted the need for rapid development of new medicines against emerging health threats.
  • Drug repurposing is an initial response, but more targeted therapies are required for sustained efforts.
  • Previous open-access compound collections have proven valuable for drug discovery.

Purpose of the Study:

  • To assemble and provide a novel collection of compounds to accelerate drug discovery for emerging infectious diseases.
  • To support the development of specifically designed therapies targeting molecular or phenotypic assays.
  • To facilitate rapid data sharing within the scientific community.

Main Methods:

  • Curated a collection of 400 compounds, the Pandemic Response Box.
  • Selected compounds based on public domain information of chemotypes in discovery/early development with known activities.
  • Prioritized compounds using expertise from medicinal chemistry.

Main Results:

  • The Pandemic Response Box is now available as a freely accessible pharmacological test set.
  • The collection comprises compounds with demonstrated utility for infectious disease research.
  • Availability is contingent on rapid sharing of generated data in the public domain.

Conclusions:

  • The Pandemic Response Box represents a significant resource for the scientific community to combat emerging infectious diseases.
  • This initiative fosters collaborative drug discovery by providing a foundation for developing targeted therapies.
  • Open access and rapid data sharing are crucial for advancing pandemic preparedness and response.