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Controversy of Adjuvant Locoregional Therapy for Node-Positive Anal Mucosal Melanoma

Stephanie K Schaub1, Edward Y Kim1

  • 1University of Washington School of Medicine, Department of Radiation Oncology, Seattle, Washington.

International Journal of Radiation Oncology, Biology, Physics
|March 14, 2022
PubMed
Abstract

No abstract available in PubMed .

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Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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