Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin-dependent diabetes mellitus: pathophysiology.

J E Gerich

    Mayo Clinic Proceedings
    |October 1, 1986
    PubMed
    Summary

    Diabetes mellitus, a common endocrine disorder, has two main types: non-insulin-dependent and insulin-dependent. Poor glycemic control significantly worsens long-term diabetes complications like retinopathy and nephropathy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of hyperthyroidism on clearance and secretion of glucagon in man.

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2011
    Same author

    Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications.

    Diabetic medicine : a journal of the British Diabetic Association·2010
    Same author

    Nateglinide, alone or in combination with metformin, is effective and well tolerated in treatment-naïve elderly patients with type 2 diabetes.

    Diabetes, obesity & metabolism·2007
    Same author

    Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease.

    Journal of thrombosis and haemostasis : JTH·2007
    Same author

    Hypoglycemic potential of nateglinide versus glyburide in patients with type 2 diabetes mellitus.

    Metabolism: clinical and experimental·2004
    Same author

    Insulin secretion, insulin sensitivity, and hepatic insulin extraction in first-degree relatives of type 2 diabetic patients.

    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2003

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Immunology

    Background:

    • Diabetes mellitus is a heterogeneous endocrine disorder with two primary forms: non-insulin-dependent (Type 2) and insulin-dependent (Type 1).
    • Type 2 diabetes involves insulin resistance and impaired secretion, while Type 1 results from autoimmune destruction of pancreatic beta cells.
    • Long-term complications such as retinopathy, nephropathy, neuropathy, and atherosclerosis are common in all diabetes patients.

    Purpose of the Study:

    • To review the current understanding of diabetes mellitus heterogeneity.
    • To highlight the significant impact of metabolic derangements on diabetes complications.
    • To underscore the rationale for glycemic control in managing diabetes.

    Main Methods:

    • Review of existing literature on diabetes mellitus.
    • Analysis of experimental animal studies.
    • Evaluation of prospective clinical studies.

    Main Results:

    • Evidence indicates metabolic derangements linked to poor glycemic control are key factors in the frequency and severity of diabetes complications.
    • Animal and clinical studies support the link between glycemic control and long-term outcomes.
    • Understanding the molecular basis of complications is ongoing.

    Conclusions:

    • Maintaining near-normal glycemia is crucial for mitigating long-term diabetes complications.
    • Effective glycemic control is a primary strategy in diabetes management.
    • Further research is needed to fully elucidate the molecular mechanisms of diabetic complications.

    Related Experiment Videos