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[Skeletal changes caused by etretinate].

H G Crespi, J A Massimo, F Gentile

    Medicina Cutanea Ibero-Latino-Americana
    |January 1, 1986
    PubMed
    Summary
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    Etretinate effectively treated generalized pustular psoriasis in a child, but long-term use caused growth delay and bone abnormalities. Close monitoring of pediatric patients on etretinate is crucial.

    Area of Science:

    • Dermatology
    • Pediatric Endocrinology

    Background:

    • Generalized pustular psoriasis is a severe skin condition.
    • Treatment options for pediatric psoriasis can be limited.

    Observation:

    • A 4-year-old male with generalized pustular psoriasis showed limited response to prednisone.
    • Etretinate treatment led to remission but was followed by growth delay and bone abnormalities upon follow-up.

    Findings:

    • Etretinate induced remission of pustular psoriasis.
    • Long-term etretinate use in a child resulted in significant growth delay and radiographically evident bone changes, including periosteal separation and demineralization.

    Implications:

    • This case highlights the potential for significant adverse effects of etretinate on pediatric skeletal development.

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  • Close clinical and radiological monitoring is essential for children undergoing etretinate therapy to mitigate risks.