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Enhancing the Stability of the Resin-Dentin Bonding Interface with Ag+- and Zn2+-Exchanged Zeolite A
He Li1, Yunzheng Wang2, Shuang Wang3
1Department of Cariology, Endodontology and Operative Dentistry, Jilin Provincial Key Laboratory of Science and Technology for Stomatology Nanoengineering, School and Hospital of Stomatology, Jilin University, 1500 Qinghua Road, Changchun 130021, P.R. China.
Abstract:
Enhancing the stability of the resin-dentin bonding interface via simultaneously improving the antibacterial, mechanical, and adhesive properties of a dental adhesive is the key to prolonging the longevity of dental restoration for caries treatment. Herein, we present the stabilization effect of Ag+- and Zn2+-exchanged zeolite A (denoted as Ag-A and Zn-A, respectively) on the resin-dentin bonding interface. Ag-A and Zn-A zeolites exhibited sustained ion release capability, outstanding biocompatibility to L929 cells (<2 mg/mL), and excellent antibacterial ability to Streptococcus mutans (minimum inhibitory concentration: 100 μg/mL for Ag-A and 200 μg/mL for Zn-A). One-step self-etching adhesives modified by Ag-A, Zn-A, or Ag-/Zn-A (1/1 in weight) zeolites with an ultralow loading of 0.2 wt % exhibited favorable antibacterial activity with the inhibition of biofilm formation by 70.33, 56.47, and 62.54%, respectively. Compared to the control group, Zn-A- and Ag-/Zn-A-modified adhesives significantly increased the wettability properties of the adhesive and the long-term resin-dentin bond strength (by ∼25%) after 5000 thermocycles of aging. The current data demonstrated that the introduction of 0.2 wt % Zn-A or Ag-/Zn-A into the adhesive remarkably enhanced the stability of the resin-dentin bonding interface. Our findings provide a new strategy to modify the dental adhesive for further optimizing the longevity of dental restorations for caries.
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