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Nanocrystals based mucosal delivery system: research advances.

Yang Liu¹, Shuyuan Shuai¹, Guiting Huang¹

¹Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, NanChang, China.

Drug Development and Industrial Pharmacy

|March 15, 2022

Summary

Nanocrystal technology enhances poorly soluble drug delivery. This review covers nanocrystal preparation methods and mucosal delivery applications for natural products, offering insights for future research.

Keywords:

Poorly soluble drugs mucosal delivery system nanocrystals preparation technology progress

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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Area of Science:

Pharmaceutical Sciences
Materials Science
Biotechnology

Background:

Poorly soluble drugs present significant challenges in drug delivery and bioavailability.
Nanocrystal technology offers a promising approach to overcome solubility limitations.
Natural products are a rich source of therapeutic compounds but often suffer from poor solubility.

Purpose of the Study:

To review the preparation methods of nanocrystals for poorly soluble natural products.
To explore the application of nanocrystals in mucosal drug delivery systems.
To provide a reference for the development of natural product-based nanocrystal preparations.

Main Methods:

Literature review of domestic and international research on nanocrystal preparation.
Analysis of studies focusing on nanocrystal applications in skin, eye, oral cavity, and nasal cavity delivery.
Synthesis of information on various nanocrystal preparation techniques.

Main Results:

Nanocrystal technology significantly improves the solubility and bioavailability of poorly soluble drugs.
Various preparation methods exist for creating drug nanocrystals.
Mucosal delivery of natural product nanocrystals shows broad application prospects.

Conclusions:

Nanocrystal technology is a versatile platform for enhancing the delivery of poorly soluble natural products.
Further research into nanocrystal preparation and mucosal delivery can unlock the therapeutic potential of natural products.
This review provides valuable insights for researchers and developers in the field of natural product drug delivery.