Related Experiment Video
Updated: Sep 30, 2025
09:38
Direct Reprogramming of Mouse Fibroblasts into Melanocytes
Published on: August 27, 2021
2.2K
Nuclear Factor Erythroid 2-Related Factor 2 in Vitiligo
V Romano-Lozano1, A Cruz-Avelar2, M L Peralta Pedrero3
1Centro Dermatológico Dr. Ladislao de la Pascua, Ciudad de México, México.
Actas Dermo-Sifiliograficas
|March 15, 2022
Summary
Vitiligo pathogenesis involves oxidative stress, impacting the protective nuclear factor erythroid factor 2 (Nrf2) pathway. Research explores Nrf2 modulation for novel vitiligo treatments.
Area of Science:
- Dermatology
- Molecular Biology
- Biochemistry
Background:
- Vitiligo is a pigmentary disorder linked to oxidative stress.
- The nuclear factor erythroid factor 2 (Nrf2) pathway protects melanocytes from oxidative damage.
- Nrf2 regulates antioxidant enzyme expression, crucial for cellular defense.
Purpose of the Study:
- To review the role of Nrf2 in vitiligo pathogenesis.
- To identify emerging therapeutic strategies targeting Nrf2 for vitiligo treatment.
Main Methods:
- Comprehensive literature search in PubMed, Ovid, Scopus, and Web of Science.
- Keywords: "Vitiligo AND nuclear factor erythroid derived 2 like 2 OR NRF2".
- Inclusion of in vitro studies, reviews, case series, cohort studies, and clinical trials.
Main Results:
- Abnormalities in Nrf2 location and function are observed in vitiligo.
- Genetic polymorphisms in Nrf2 increase vitiligo risk.
- Investigational molecules targeting Nrf2 show therapeutic potential.
Conclusions:
- Nrf2 pathway dysfunction contributes to vitiligo.
- Targeting Nrf2 represents a promising avenue for vitiligo treatment development.
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