Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

6.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
6.0K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

3.8K
The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
3.8K
General Transcription Factors01:30

General Transcription Factors

5.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.7K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.9K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.9K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.8K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.8K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

3.9K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed cytoreductive nephrectomy in adults with metastatic renal cell carcinoma and vena cava tumor thrombus treated with immunotherapy-based neoadjuvant therapy: A systematic review.

Actas urologicas espanolas·2025
Same author

Translation and Cross-Cultural Adaptation of Health Assessment Tools.

Actas dermo-sifiliograficas·2017
See all related articles

Related Experiment Video

Updated: Sep 30, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.2K

Nuclear Factor Erythroid 2-Related Factor 2 in Vitiligo.

V Romano-Lozano1, A Cruz-Avelar2, M L Peralta Pedrero3

  • 1Centro Dermatológico Dr. Ladislao de la Pascua, Ciudad de México, México.

Actas Dermo-Sifiliograficas
|March 15, 2022
PubMed
Summary

Vitiligo pathogenesis involves oxidative stress, impacting the protective nuclear factor erythroid factor 2 (Nrf2) pathway. Research explores Nrf2 modulation for novel vitiligo treatments.

Keywords:
Antioxidant responseNrf2Respuesta antioxidanteVitiligoVitíligo

More Related Videos

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

1.2K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.4K

Related Experiment Videos

Last Updated: Sep 30, 2025

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

2.2K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

1.2K
Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.4K

Area of Science:

  • Dermatology
  • Molecular Biology
  • Biochemistry

Background:

  • Vitiligo is a pigmentary disorder linked to oxidative stress.
  • The nuclear factor erythroid factor 2 (Nrf2) pathway protects melanocytes from oxidative damage.
  • Nrf2 regulates antioxidant enzyme expression, crucial for cellular defense.

Purpose of the Study:

  • To review the role of Nrf2 in vitiligo pathogenesis.
  • To identify emerging therapeutic strategies targeting Nrf2 for vitiligo treatment.

Main Methods:

  • Comprehensive literature search in PubMed, Ovid, Scopus, and Web of Science.
  • Keywords: "Vitiligo AND nuclear factor erythroid derived 2 like 2 OR NRF2".
  • Inclusion of in vitro studies, reviews, case series, cohort studies, and clinical trials.

Main Results:

  • Abnormalities in Nrf2 location and function are observed in vitiligo.
  • Genetic polymorphisms in Nrf2 increase vitiligo risk.
  • Investigational molecules targeting Nrf2 show therapeutic potential.

Conclusions:

  • Nrf2 pathway dysfunction contributes to vitiligo.
  • Targeting Nrf2 represents a promising avenue for vitiligo treatment development.