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Updated: Sep 30, 2025

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
Published on: February 23, 2024
OGT as potential novel target: Structure, function and inhibitors
Ning Zhang1, Hongli Jiang1, Kexin Zhang1
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 211198, PR China.
Abstract:
O-linked N-acetylglucosamine transferase (OGT), a key protein in O-linked N-acetylglucosamine (O-GlcNAc) post-translational modification, catalyzes O-GlcNAcylation by linking GlcNAc from glycosyl donors to protein Ser/Thr residues to regulate multiple biological processes. OGT has become a popular research topic in the field of glycobiology as a potential target. This report consists of three parts, namely: the basic information of OGT, the relationship between OGT and diseases, and the research progress of OGT inhibitors. This report aims to improve the understanding of OGT-related fields from the perspective of its structure. OGT inhibitors could aid the effective and efficient investigation of the O-GlcNAcylation mechanism, and provide new ideas and methods for the treatment of related diseases.
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