Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevated plasma renin activity associated with renal dysfunction.

B Kehoe, G R Keeton, C Hill

    Nephron
    |January 1, 1986
    PubMed
    Summary

    Elevated plasma renin activity (PRA) is linked to early kidney dysfunction in at-risk patients. This suggests the renin-angiotensin system may play a role in the prerenal phase of renal failure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    New measurements of high-momentum nucleons and short-range structures in nuclei.

    Physical review letters·2012
    Same author

    The long-term outcome of hepatic artery thrombosis after liver transplantation in children: role of urgent revascularization.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
    Same author

    Burnout in therapy radiographers in the UK.

    The British journal of radiology·2012
    Same author

    Search for a vectorlike quark with charge 2/3 in t+Z events from pp collisions at √s=7 TeV.

    Physical review letters·2012
    Same author

    Search for B(s)(0) → μ+ μ- and B(0) → μ+ μ- decays in pp collisions at sqrt[s] = 7 TeV.

    Physical review letters·2011
    Same author

    Search for new physics with a monojet and missing transverse energy in pp collisions at √s = 7 TeV.

    Physical review letters·2011

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Biochemistry

    Background:

    • Elevated plasma renin activity (PRA) is observed in patients with established acute renal failure.
    • The role of PRA in the early stages of renal dysfunction remains unclear.

    Purpose of the Study:

    • To investigate the association between PRA and renal dysfunction in patients at risk of acute renal failure.
    • To explore the relationship between PRA, renal function, and tubular injury markers.

    Main Methods:

    • Serial measurements of PRA, renal function (plasma urea, creatinine), and urinary beta 2-microglobulin in 53 at-risk patients.
    • Patients were categorized based on renal function (normal vs. abnormal).
    • Statistical analysis included linear regression to assess correlations.

    Main Results:

    • Significantly higher mean PRA levels in patients with abnormal renal function (29 ng/ml/h) compared to normal renal function (5.2 ng/ml/h).
    • Elevated urinary beta 2-microglobulin levels were also observed in the abnormal renal function group.
    • A significant positive correlation was found between PRA and beta 2-microglobulin (r=0.526, p<0.001).

    Conclusions:

    • The study demonstrates an association between PRA and renal dysfunction/tubular injury in the prerenal phase of renal failure.
    • These findings suggest a potential role for the renin-angiotensin system in the early stages of renal dysfunction.
    • Further research is needed to determine if the renin-angiotensin system directly contributes to established acute tubular necrosis.

    Related Experiment Videos