Extracorporeal Cardiopulmonary Resuscitation Guided by End-Tidal Carbon Dioxide-a Porcine Model

Extracorporeal membrane cardiopulmonary resuscitation (ECPR) during cardiopulmonary resuscitation (CPR) for selected cases and end-tidal carbon dioxide (ETCO₂) could be used to guide initiation of ECPR. Ventricular fibrillation was induced in 12 pigs and CPR was performed until ETCO₂ fell below 10 mmHg; then, ECPR was performed. Animals were divided into group short (G_Short) and group long (G_Long), according to time of CPR. Carotid blood flow was higher (p = 0.02) and mean arterial blood pressure lower in G_Long during CPR (p < 0.05). B-Lactate was lower and pH higher in G_Short (p < 0.01). In microdialysis lactate-pyruvate ratio, glycerol and glutamate increased in both groups during CPR, but considerably in G_Long (p < 0.01). No difference could be seen in histopathology of the brain or kidney post-ECPR. No apparent histological differences of tissue damage in brains or levels of S100B in plasma were detected between groups. This might suggest that ETCO₂ could be used as a marker for brain injury following ECPR.