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Updated: Sep 30, 2025
09:20
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Prognostic Role of Pulmonary Function in Patients With Heart Failure With Reduced Ejection Fraction
Hao-Chih Chang1,2, Wei-Ming Huang3,2, Wen-Chung Yu3,2,4
1Department of Medicine Taipei Veterans General Hospital Yuanshan and Suao Branch Yilan Taiwan.
Journal of the American Heart Association
|March 15, 2022
Summary
Ventilatory abnormalities are common in heart failure with reduced ejection fraction patients with pulmonary hypertension. However, impaired lung function predicts mortality only in patients without pulmonary hypertension.
Area of Science:
- Cardiology
- Pulmonology
- Internal Medicine
Background:
- Ventilatory abnormalities and pulmonary hypertension (PH) are common in heart failure with reduced ejection fraction (HFrEF).
- The association and prognostic impact of these conditions in HFrEF patients require further investigation.
Purpose of the Study:
- To investigate the association between ventilatory abnormalities and PH in HFrEF patients.
- To determine the prognostic significance of ventilatory abnormalities and PH on long-term survival in HFrEF.
Main Methods:
- 440 ambulatory HFrEF patients (LVEF ≤40%) underwent echocardiography and spirometry.
- Pulmonary arterial systolic pressure was estimated to define PH (>50 mm Hg).
- All-cause mortality was assessed over 5 years.
Main Results:
- Patients with PH exhibited significantly reduced lung volumes (TLC, FVC, FEV1).
- Reduced lung function (TLC, FVC, FEV1) correlated with mortality in patients without PH, but not in those with PH.
- Impaired pulmonary function was linked to higher mortality in non-PH HFrEF patients, but not in PH HFrEF patients.
Conclusions:
- Ventilatory abnormalities are more prevalent in HFrEF patients with PH.
- Ventilatory defects impact long-term survival exclusively in HFrEF patients without PH, irrespective of functional capacity.
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