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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Click-Chemistry Based Fluorometric Assay for Apolipoprotein N-acyltransferase from Enzyme Characterization to High-Throughput Screening
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[Lipoprotein (a) :NSFA consensus].

Vincent Durlach1, Eduardo Anglés-Cano2

  • 1Université de Champagne-Ardenne, UMR CNRS 7369 MEDyC, pôle thoracique et cardiovasculaire de Reims, CHU de Reims, Reims, France.

La Revue Du Praticien
|March 15, 2022
PubMed
Summary
This summary is machine-generated.

Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerosis and thrombosis. Measuring Lp(a) aids cardiovascular risk assessment and monitoring new lipid-lowering therapies.

Keywords:
Cardiovascular riskCholesterol, LDLLipoprotein (a)

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Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Genetics

Background:

  • Lipoprotein(a) [Lp(a)] comprises low-density lipoprotein (LDL) bound to apolipoprotein(a) [apo(a)].
  • Its structure, similar to plasminogen, confers prothrombotic and antifibrinolytic properties.
  • Lp(a) contributes to atherosclerosis by accumulating in arterial intima and depositing cholesterol and oxidized phospholipids.

Purpose of the Study:

  • To highlight the significance of Lipoprotein(a) [Lp(a)] in cardiovascular risk.
  • To discuss the role of Lp(a) in atherothrombosis and atherosclerosis progression.
  • To emphasize the clinical utility of Lp(a) assays for risk stratification and monitoring novel therapies.

Main Methods:

  • Review of existing literature on Lipoprotein(a) [Lp(a)].
  • Discussion of Lp(a) structure, function, and clinical implications.
  • Examination of Lp(a) measurement challenges and therapeutic strategies.

Main Results:

  • Plasma concentrations of Lp(a) exhibit wide genetic variability, independent of age, gender, or lifestyle.
  • Elevated Lp(a) levels are directly correlated with increased atherothrombotic risk.
  • Lp(a) assays are valuable for risk stratification and evaluating new lipid-lowering treatments.

Conclusions:

  • Lipoprotein(a) [Lp(a)] is a critical, genetically influenced factor in cardiovascular disease.
  • Accurate Lp(a) measurement is essential for personalized risk assessment.
  • Emerging therapies targeting Lp(a) show promise for managing high cardiovascular risk patients.