Related Experiment Video
Updated: Sep 30, 2025
07:34
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
811
The association between histological prostatitis and benign prostatic hyperplasia: a single-center retrospective
Jinze Li1,2, Yunxiang Li3, Dehong Cao1
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Summary
Histological prostatitis (HP) is linked to larger prostate volumes, more severe lower urinary tract symptoms (LUTS), and increased acute urinary retention (AUR) risk in men with benign prostatic hyperplasia (BPH). HP may influence BPH progression.
Area of Science:
- Urology
- Pathology
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Histological prostatitis (HP) is frequently observed in prostate tissue but its clinical significance in BPH is not fully understood.
Purpose of the Study:
- To investigate the association between histological prostatitis (HP) and clinical parameters in patients with benign prostatic hyperplasia (BPH).
Main Methods:
- Retrospective analysis of 196 BPH patients undergoing transurethral resection of the prostate.
- Patients were categorized into groups based on the presence or absence of HP via H&E staining.
- Comparison of clinical parameters including acute urinary retention (AUR) rate, prostate volume (PV), International Prostate Symptom Score (IPSS), urinary flow rates, and serum markers.
Main Results:
- The BPH with HP group exhibited significantly higher AUR rates, larger prostate volumes (PV), and greater total IPSS and storage symptoms compared to the BPH without HP group (p < 0.05).
- No significant differences were observed in voiding symptoms (IPSS-voiding), post-void residual volume, maximum urinary flow rate, serum sex hormones, or systemic inflammation indicators between the groups (p > 0.05).
Conclusions:
- Histological prostatitis is associated with increased prostate volume, more severe lower urinary tract symptoms (LUTS), and a higher risk of acute urinary retention (AUR) in BPH patients.
- HP may play a crucial role in the development and clinical progression of benign prostatic hyperplasia.
