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[The Langerhans system. Definition. Physiologic and pathologic modifications].

S Barbey, C Nezelof

    Pathologie-Biologie
    |April 1, 1986
    PubMed
    Summary
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    This review details the Langerhans cell (LC) system, a unique part of the mononuclear phagocyte system. It explores variations in these cells during normal, experimental, and disease states.

    Area of Science:

    • Immunology
    • Cell Biology
    • Dermatology

    Context:

    • The Langerhans cell (LC) system, comprising LC, indeterminate epidermal cells, lymphoid interdigitating cells, and lymph veiled cells, is recognized as a distinct subpopulation within the mononuclear phagocyte system.
    • Understanding the nuances of this system is crucial for comprehending immune responses within epithelial tissues.

    Purpose:

    • To provide a comprehensive overview of the salient features of the Langerhans cell system.
    • To analyze the qualitative and quantitative variations of these cells across physiological, experimental, and pathological conditions.

    Summary:

    • The Langerhans cell system, a specialized group of mononuclear phagocytes, includes Langerhans cells (LCs), indeterminate epidermal cells, lymphoid interdigitating cells, and lymph veiled cells.

    Related Experiment Videos

  • This review highlights key characteristics and discusses how the numbers and types of these cells change during normal bodily functions, experimental manipulations, and disease processes.

    • Impact:

    • Offers insights into the dynamic nature of immune cells in the skin and lymph nodes.
    • Provides a foundational resource for researchers studying immune cell heterogeneity and function in various biological contexts.