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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Related Experiment Video

Updated: Sep 30, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Establishing a Multicenter Network for Patients With Thyroid Nodules and Cancer: Effects on Referral Patterns.

Sam P J van Dijk1, Ivona Lončar1, Elizabeth van Veen-Berkx2

  • 1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 15, 2022
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Summary

Establishing a Thyroid Network for thyroid nodules and cancer care reduced second opinions by 70% and increased specialist satisfaction. This model can be applied to other regions and specialties.

Keywords:
multidisciplinary tumor boardsthyroid

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Area of Science:

  • Endocrinology
  • Oncology
  • Health Services Research

Background:

  • Thyroid nodules and cancer require specialized, multidisciplinary care.
  • Regional collaboration can optimize patient pathways and reduce healthcare fragmentation.

Purpose of the Study:

  • To qualitatively evaluate the Thyroid Network and quantitatively analyze second opinion referrals for thyroid cancer patients.
  • To assess the impact of a regional network on patient care and specialist collaboration.

Main Methods:

  • Prospective observational study of patients with thyroid nodules and cancer.
  • Implementation of regional multidisciplinary tumor boards and a standardized care pathway.
  • Qualitative interviews with stakeholders and quantitative analysis of second opinion referrals.

Main Results:

  • Second opinions decreased significantly from 30% to 7% (P = .001) within two years.
  • Patient referrals remained stable, indicating consistent demand for care.
  • Qualitative feedback highlighted high value placed on the uniform care pathway and multidisciplinary tumor boards.

Conclusions:

  • A regional Thyroid Network, incorporating multidisciplinary tumor boards and a care pathway, effectively reduced second opinions.
  • The network fostered high satisfaction among participating specialists.
  • The model shows potential for expansion to other regions and medical specialties.