Attention Gate Based Dual-Pathway Network for Vertebra Segmentation of X-Ray Spine Images

Automatic spine and vertebra segmentation from X-ray spine images is a critical and challenging problem in many computer-aid spinal image analysis and disease diagnosis applications. In this paper, a two-stage automatic segmentation framework for spine X-ray images is proposed, which can firstly locate the spine regions (including backbone, sacrum and ilium) in the coarse stage and then identify eighteen vertebrae (i.e., cervical vertebra 7, thoracic vertebra 1-12 and lumbar vertebra 1-5) with isolate and clear boundary in the fine stage. A novel Attention Gate based dual-pathway Network (AGNet) composed of context and edge pathways is designed to extract semantic and boundary information for segmentation of both spine and vertebra regions. Multi-scale supervision mechanism is applied to explore comprehensive features and an Edge aware Fusion Mechanism (EFM) is proposed to fuse features extracted from the two pathways. Some other image processing skills, such as centralized backbone clipping, patch cropping and convex hull detection are introduced to further refine the vertebra segmentation results. Experimental validations on spine X-ray images dataset and vertebrae dataset suggest that the proposed AGNet achieves superior performance compared with state-of-the-art segmentation methods, and the coarse-to-fine framework can be implemented in real spinal diagnosis systems.