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The transition in frequency of Y chromatin in males during the neonatal period

K Iijima, M Higurashi, M Hirayama

    Human Genetics
    |June 27, 1978
    PubMed

    Insights

    The presence of Y chromatin in male infants significantly increases after birth, reaching adult levels by one month. This finding is crucial for understanding male development and Y chromosome behavior.

    Area of Science:

    • Genetics
    • Cell Biology
    • Human Development

    Background:

    • Y chromatin, a fluorescent marker of the Y chromosome, is present in cell nuclei.
    • Its frequency can vary and may be indicative of biological processes.

    Purpose of the Study:

    • To investigate the developmental changes in Y chromatin frequency in male infants.
    • To compare Y chromatin levels in newborns, infants, and adults.

    Main Methods:

    • Analysis of blood smears from male infants at different ages (newborn, 3 months, 1 month).
    • Quantification of Y chromatin-positive cells using fluorescence microscopy.
    • Statistical comparison of Y chromatin frequencies across age groups.

    Main Results:

    • Newborn males had a significantly lower Y chromatin frequency (36.16%) compared to older infants and adults.
    • Y chromatin frequency increased daily after birth.
    • By one month, the frequency reached 55.07%, not significantly different from adult males (57.08%).

    Conclusions:

    • Y chromatin frequency in males undergoes significant developmental changes post-birth.
    • Adult Y chromatin levels are attained within the first month of life.
    • This study provides insights into the dynamic nature of Y chromosome expression during early male development.

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