Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.3K
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.7K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.7K
Bone Remodeling01:40

Bone Remodeling

38.7K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of fatigue on rheumatic diseases: Current perspectives.

Best practice & research. Clinical rheumatology·2026
Same author

[Osteoarthritis: epidemiology, pathophysiology, and conservative treatment options].

Innere Medizin (Heidelberg, Germany)·2026
Same author

Recombinant zoster vaccine in patients with inflammatory rheumatic diseases: efficacy, long-term protection and safety under immunosuppression.

RMD open·2026
Same author

Bariatric surgery and subsequent weight loss lead to a reversal of peripheral blood monocytosis in obesity.

International journal of obesity (2005)·2026
Same author

Is there a link between non-steroidal anti-inflammatory drugs and cardiovascular risk in patients with inflammatory arthritis?

Atherosclerosis plus·2026
Same author

Atypical presentation of granulomatosis with polyangiitis mimicking metastatic breast cancer.

Kidney international·2026

Related Experiment Video

Updated: Sep 30, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.3K

[Osteoarthritis: what's new?]

Marco Krasselt1, Christoph Baerwald1

  • 1Rheumatologie, Medizinische Klinik III - Endokrinologie, Nephrologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR.

Deutsche Medizinische Wochenschrift (1946)
|March 15, 2022
PubMed
Summary

Osteoarthritis (OA) management focuses on patient education and weight loss. While NSAIDs and other analgesics offer pain relief, new treatments like tanezumab and lorecivivint show limited success, with further research pending.

More Related Videos

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.2K
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.2K

Related Experiment Videos

Last Updated: Sep 30, 2025

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

1.3K
Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

6.2K
Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

5.2K

Area of Science:

  • Orthopedics
  • Rheumatology
  • Gerontology

Background:

  • Osteoarthritis (OA) is a prevalent degenerative joint disease, with increasing incidence due to an aging population.
  • Key risk factors include advanced age, trauma, biomechanical stress, and obesity, which contribute to joint inflammation.
  • Cellular senescence and excess adiposity are implicated in promoting joint inflammation via inflammatory cytokine production by senescent chondrocytes and adipocytes.

Purpose of the Study:

  • To review current understanding of osteoarthritis pathogenesis, risk factors, and therapeutic strategies.
  • To evaluate the efficacy and limitations of existing OA treatments.
  • To discuss emerging therapeutic targets and their current developmental status.

Main Methods:

  • Literature review of osteoarthritis epidemiology, risk factors, and treatment modalities.
  • Analysis of current pharmacological and non-pharmacological interventions for OA.
  • Assessment of recent clinical trial data for novel OA therapeutics.

Main Results:

  • Patient education and weight loss are primary therapeutic cornerstones for osteoarthritis management.
  • NSAIDs, acetaminophen, and tramadol are common analgesics, but have contraindications and limitations.
  • Topical NSAIDs and intraarticular glucocorticoids offer localized pain relief, particularly for knee OA.

Conclusions:

  • Nutritional supplements like chondroitin and glycosaminoglycans may be considered as adjunctive therapy, though not universally recommended.
  • The development of novel OA treatments faces challenges, exemplified by the setbacks with the NGF-antibody tanezumab and early-phase Wnt inhibitor lorecivivint.
  • Further investigation and clinical trials are necessary to identify effective, safe, and disease-modifying therapies for osteoarthritis.