Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cannabinoid pharmacology.

W L Dewey

    Pharmacological Reviews
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cannabinoids primarily affect the central nervous system, presenting a challenge for therapeutic use due to side effects. However, these compounds exhibit low toxicity, with rare lethal overdose effects in humans.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Opioid-like adverse effects of tianeptine in male rats and mice.

    Psychopharmacology·2022
    Same author

    Sensitization of enteric neurons to morphine by HIV-1 Tat protein.

    Neurogastroenterology and motility·2015
    Same author

    Site and mechanism of morphine tolerance in the gastrointestinal tract.

    Neurogastroenterology and motility·2014
    Same author

    Reversal of morphine analgesic tolerance by ethanol in the mouse.

    The Journal of pharmacology and experimental therapeutics·2013
    Same author

    The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy.

    The Journal of pharmacology and experimental therapeutics·2009
    Same author

    A survey of the teaching of pain control at the predoctoral level.

    Anesthesia progress·2009
    Same journal

    Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential.

    Pharmacological reviews·2026
    Same journal

    Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.

    Pharmacological reviews·2026
    Same journal

    Translational medications development for methamphetamine use disorder: A systematic review of preclinical, human laboratory, and clinical research.

    Pharmacological reviews·2026
    Same journal

    Reharnessing the therapeutic potential of gallium-based compounds in oncology: From the laboratory to the clinic.

    Pharmacological reviews·2026
    Same journal

    Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.

    Pharmacological reviews·2026
    Same journal

    International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.

    Pharmacological reviews·2026
    See all related articles

    Area of Science:

    • Pharmacology
    • Neuroscience

    Background:

    • Cannabinoids exhibit a wide range of effects, primarily impacting the central nervous system.
    • A significant challenge in cannabinoid research is identifying therapeutic agents with efficacy below the dose threshold for side effects.

    Purpose of the Study:

    • To review the pharmacological characteristics of cannabinoids, focusing on their central nervous system effects and toxicity profiles.
    • To discuss the implications of cannabinoid pharmacology for potential therapeutic applications.

    Main Methods:

    • Review of existing literature on cannabinoid pharmacology in animal models and humans.
    • Analysis of dose-response relationships for therapeutic and toxic effects.

    Main Results:

    • Cannabinoids distribute widely in the brain due to high lipid solubility.

    Related Experiment Videos

  • Low toxicity and rare instances of lethal overdose are characteristic of cannabinoids in humans.
  • Most observed effects are attributed to direct central nervous system actions, though peripheral effects are possible.

    • Conclusions:

    • Cannabinoids produce a unique behavioral syndrome in both animals and humans.
    • Further research into molecular mechanisms is needed to fully elucidate cellular-level actions.
    • The therapeutic window for cannabinoids remains a key area for investigation.