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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Related Experiment Video

Updated: Sep 30, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
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Targeted Immunotherapy for Autoimmune Disease.

Seung Min Jung1, Wan-Uk Kim1

  • 1Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Immune Network
|March 16, 2022
PubMed
Summary
This summary is machine-generated.

Current autoimmune disease treatments, including cytokine inhibitors and B cell therapies, show promise but have limitations. Emerging strategies focus on immune tolerance induction for improved efficacy and safety in autoimmune conditions.

Keywords:
Autoimmune diseaseBiologic therapyInvestigational drugsMolecular targeted therapyProtein kinase inhibitors

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Area of Science:

  • Immunology
  • Pharmacology
  • Rheumatology

Background:

  • Biologics and small molecule inhibitors targeting cytokines and kinases are standard treatments for autoimmune diseases.
  • Therapies inhibiting TNF, IL-6, IL-17, IL-23, and B cells have revolutionized treatment for conditions like rheumatoid arthritis and lupus.
  • Targeting co-stimulatory molecules and JAK kinases offers new therapeutic avenues for autoimmune and hematologic disorders.

Purpose of the Study:

  • To review current and emerging therapeutic strategies for autoimmune diseases.
  • To highlight the advancements in targeting specific immune pathways and molecules.
  • To address the unmet needs in therapeutic efficacy and safety.

Main Methods:

  • Review of established and novel therapeutic targets in autoimmune diseases.
  • Analysis of biologics, small molecule inhibitors, and cell-based therapies.
  • Exploration of emerging approaches like immune tolerance induction.

Main Results:

  • Significant therapeutic advancements have been achieved through targeted inhibition of inflammatory mediators and immune cells.
  • Janus kinase (JAK) inhibitors show considerable interest for autoimmune and hematologic diseases.
  • Existing therapies still present unmet needs regarding efficacy and safety.

Conclusions:

  • While current therapies have transformed autoimmune disease management, further innovation is required.
  • Emerging therapies aim to achieve immune tolerance, offering potential for enhanced efficacy and safety.
  • Advanced molecular engineering techniques are key to developing next-generation autoimmune treatments.