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Updated: Aug 9, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Immune mechanisms and the action of interferon in chronic hepatitis B virus infection
Abstract:
Cytotoxic T lymphocytes can eliminate cells infected with hepatitis B virus. A defect of T lymphocyte-mediated cytolysis seems to exist in chronic hepatitis B infection. T cell-mediated lysis is dependent on HLA antigens of the infected host and this may explain the increased or decreased frequency of particular HLA antigens in chronic carriers of hepatitis B virus. This virus may decrease the concentration of HLA antigens expressed on liver cells. Interferon increases the HLA antigen expression on T lymphocytes and hepatocytes, thereby enhancing T lymphocyte-mediate lysis of infected liver cells and elimination of the hepatitis B virus.
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