Related Experiment Video

Updated: Sep 30, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

The opioid use disorder core outcomes set (OUD-COS) for treatment research: findings from a Delphi consensus study

Niranjan S Karnik1, John Marsden2, Connor McCluskey1

  • 1Institute for Juvenile Research, Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.

Addiction (Abingdon, England)
|March 16, 2022
PubMed
Abstract

Insights

Researchers developed a core outcomes set for opioid use disorder (OUD) treatments. This standardized set includes patient-reported, clinician-reported, and administrative outcomes for OUD research.

Area of Science:

  • Addiction Medicine
  • Clinical Research Methodology
  • Public Health

Background:

  • Significant heterogeneity exists in outcome measures for opioid use disorder (OUD) treatments.
  • A standardized approach is needed to evaluate OUD treatment efficacy and effectiveness.

Purpose of the Study:

  • To develop the US National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network (CTN) opioid use disorder core outcomes set (OUD-COS).

Main Methods:

  • A four-round e-Delphi expert panel consensus study was conducted.
  • A panel of 25 experts, including practitioners and researchers, participated.
  • Candidate items were ranked on a 9-point scale, with a 70% consensus criterion.

Main Results:

  • Consensus was reached on five core outcomes for OUD treatment.
  • These include two patient-reported outcomes: global impression of improvement and incident non-fatal overdose.
  • One clinician-reported outcome (illicit/non-medical drug toxicology) and two administrative outcomes (duration of treatment, fatal opioid poisoning) were identified.

Conclusions:

  • The e-Delphi study successfully produced the NIDA CTN OUD-COS version 1.
  • This core outcomes set will standardize research on OUD treatment efficacy and effectiveness.
Keywords:
Core outcomes setDelphi consensusUS National Institute on Drug Abuseefficacy and effectiveness researchopioid treatment cascadeopioid use disorder

More Related Videos

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior12:20

Use of the Operant Orofacial Pain Assessment Device OPAD to Measure Changes in Nociceptive Behavior

Published on: June 10, 2013

21.3K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.8K

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
2.2K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
467
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
410
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
766
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
234
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.2K