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Updated: Sep 30, 2025
08:37
Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
Published on: November 8, 2017
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Thrombospondins in human aortic aneurysms
Emma Plana1,2, Julia Oto2, Pilar Medina2
1Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, Valencia, Spain.
IUBMB Life
|March 16, 2022
Summary
Thrombospondins, proteins crucial for vascular health, are increasingly studied for their role in aortic aneurysms. Research highlights their potential as biomarkers and therapeutic targets, especially in human samples.
Area of Science:
- Biochemistry
- Vascular Biology
- Pathology
Background:
- Thrombospondins are matricellular proteins involved in biological and pathological processes.
- Their role in vascular disorders, particularly aortic aneurysms, is gaining attention.
- Aortic aneurysms involve impaired vascular remodeling and extracellular matrix protein dysfunction.
Purpose of the Study:
- To review current findings on thrombospondins in aortic aneurysm development.
- To emphasize the importance of studies on human samples.
- To explore thrombospondins as potential biomarkers and therapeutic targets.
Main Methods:
- Literature review of recent findings.
- Focus on studies involving human samples.
- Analysis of in vitro and in vivo model studies.
Main Results:
- Thrombospondin dysregulation is implicated in aortic aneurysm development.
- Human sample studies are crucial for validating molecular mechanisms.
- Thrombospondins show potential as biomarkers and therapeutic targets.
Conclusions:
- Thrombospondins play a significant role in aortic aneurysm pathogenesis.
- Further research in human samples is needed to confirm their clinical utility.
- Targeting thrombospondins may offer novel therapeutic strategies for aortic aneurysms.
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