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Related Experiment Video

Updated: Sep 30, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

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Biomarker ratios.

Adam Cawley1, Bethany Keen2, Kathy Tou2

  • 1Australian Racing Forensic Laboratory, Racing NSW, Sydney, New South Wales, Australia.

Drug Testing and Analysis
|March 16, 2022
PubMed
Summary

Biomarker ratios using endogenous reference compounds (ERCs) offer significant potential across various scientific fields. This study explores their application in clinical, forensic, and antidoping contexts, highlighting an under-researched area.

Keywords:
antidopingbiomarkerclinicalendogenous reference compoundforensicratioveterinary residues

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Area of Science:

  • Analytical Chemistry
  • Biochemistry
  • Forensic Science

Background:

  • Biomarker measurements are crucial in diagnostics and monitoring.
  • The use of ratios for biomarker quantification is an emerging concept.
  • Endogenous reference compounds (ERCs) offer a stable basis for ratio measurements.

Purpose of the Study:

  • To explore the detailed concept of biomarker measurements using ratios.
  • To highlight the potential of biomarkers incorporating ERCs.
  • To discuss applications in clinical, forensic, and antidoping fields.

Main Methods:

  • Literature review and conceptual analysis.
  • Discussion of existing and potential applications.
  • Case study examples from relevant fields.

Main Results:

  • The concept of biomarker ratios is underexplored despite its potential.
  • ERCs can enhance the reliability and accuracy of biomarker measurements.
  • Ratio-based biomarker approaches are applicable in diverse areas.

Conclusions:

  • Biomarker ratios incorporating ERCs represent a promising analytical strategy.
  • Further research is warranted to fully realize the potential of this approach.
  • This method has broad implications for clinical diagnostics, forensics, and sports integrity.