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Covid-19 Vaccines Available in India
Mohammad Mukim1,2, Pratishtha Sharma3, Mohsina Patweker4
1Department of Pharmacology, Dr. A.P.J Abdul Kalam University, Indore (M.P.) India - 452016.
Combinatorial Chemistry & High Throughput Screening
|March 16, 2022
Summary
This review compares India
Area of Science:
- Immunology and Vaccinology: Focus on SARS-CoV-2 vaccine efficacy and immune response.
- Public Health: Evaluation of approved COVID-19 vaccines in India.
Background:
- India has approved Covaxin (BBV152), Covishield (AZD1222), and Sputnik V for COVID-19 prevention.
- Understanding the efficacy, dosage intervals, and immune responses of these vaccines is crucial for public health strategies.
Approach:
- Review of clinical data on Covaxin, Covishield, and Sputnik V, including efficacy rates and seroconversion.
- Analysis of vaccine-induced antibody and cellular immune responses, including T-cell proliferation and IgG titers.
- Comparison of dosage intervals and adverse reactions across the reviewed vaccines.
Key Points:
- Covishield demonstrates 90% efficacy, Covaxin 78-81%, and Sputnik V 92.2%.
- Vaccine schedules vary: Covaxin (4-6 weeks), Covishield (12-16 weeks), and Sputnik V (21 days).
- All vaccines induce significant antibody and cellular immune responses, with Covishield showing high IgG GMT levels.
Conclusions:
- Covaxin, Covishield, and Sputnik V are effective vaccines against COVID-19, each with distinct efficacy and immune response profiles.
- Further research is needed to identify the optimal protective dose for Covaxin.
- The reviewed vaccines contribute to India's strategy for controlling the COVID-19 pandemic.
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