Hemodiafiltration (HDF) versus expanded hemodialysis (HDx)
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Updated: Sep 30, 2025

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
Francisco Maduell1, José Jesús Broseta1
1Department of Nephrology and Renal Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain.
Abstract:
Medium cutoff (MCO) membranes have resulted in a novel dialyzer class designed to improve membrane permeability and have been postulated as an alternative to online hemodiafiltration since MCO membranes may achieve similar solute clearances. These membranes have been incorporated into clinical practice, and the term expanded HD (HDx) has been proposed to differentiate from high-flux hemodialysis. Efficacy, safety, and quality of life comparison of HDF versus HDx have been reviewed in this article.
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