Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

363
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
363
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

6.0K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial Ca<sup>2+</sup> efflux controls neuronal metabolism and long-term memory across species.

Nature metabolism·2026
Same author

Clinical Outcomes Associated with the Use of a Family-Based Digital Support Program in Patients with Pharmacologic Treatment for Obesity.

Journal of clinical medicine·2026
Same author

Dorsal hippocampus mediates light-tone associations in male mice.

eLife·2025
Same author

Potentiation of mitochondrial function by mitoDREADD-G<sub>s</sub> reverses pharmacological and neurodegenerative cognitive impairment in mice.

Nature neuroscience·2025
Same author

Projecting neurons from the lateral entorhinal cortex to the basolateral amygdala mediate the encoding of incidental odor-taste associations.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.

Nature communications·2024

Related Experiment Video

Updated: Sep 30, 2025

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
14:25

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

Published on: September 21, 2019

7.4K

Astroglial cannabinoid signaling and behavior.

Carla Ramon-Duaso1, Ana Rocio Conde-Moro1, Arnau Busquets-Garcia1

  • 1Cell-Type Mechanisms in Normal and Pathological Behavior Research Group, Neuroscience Programme, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.

Glia
|March 16, 2022
PubMed
Summary

Astrocyte cannabinoid signaling, particularly through type-1 receptors, significantly influences behavior by modulating neuronal activity. This review explores these roles and future research directions in neuroscience.

Keywords:
D-serineastrocytescannabinoid receptorcognitionlactaterodent behaviorsocial behavior

More Related Videos

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.3K
Administration of &#916;9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

262

Related Experiment Videos

Last Updated: Sep 30, 2025

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans
14:25

Synthesis of a Deuterated Standard for the Quantification of 2-Arachidonoylglycerol in Caenorhabditis elegans

Published on: September 21, 2019

7.4K
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
12:47

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates

Published on: March 20, 2014

14.3K
Administration of &#916;9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

262

Area of Science:

  • Neuroscience
  • Astroglial Biology
  • Behavioral Science

Background:

  • Advanced neuroscience techniques reveal astrocytes' critical role in behavior.
  • Astrocytes, once considered mere support cells, are now known to actively modulate neuronal functions.

Approach:

  • This review synthesizes current research on astroglial type-1 cannabinoid receptors.
  • It examines how these receptors influence behavioral responses.
  • The review highlights emerging research avenues.

Key Points:

  • Type-1 cannabinoid receptors are functionally present in astrocytes.
  • Astroglial cannabinoid signaling is implicated in various behavioral controls.
  • Astrocytes integrate neuronal activity and release gliotransmitters to shape behavior.

Conclusions:

  • Astroglial cannabinoid signaling is a key regulator of behavior.
  • Further research into astroglial cannabinoid pathways promises new insights into brain function and behavior.