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Related Experiment Video

Updated: Sep 30, 2025

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
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Microspheres and their Potential in Endodontic Regeneration Application.

Ting Yang, Li Xie, Rui Tao Zhang

    The Chinese Journal of Dental Research
    |March 16, 2022
    PubMed
    Summary

    Microspheres are ideal injectable scaffolds for endodontic regeneration due to their size and ability to deliver biologics. These cell-laden microspheres show great promise for dental pulp regeneration and tissue engineering applications.

    Keywords:
    dental pulpendodontic regenerationmicrocapsulesmicrocarriersmicrospheres

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    Area of Science:

    • Biomedical Engineering
    • Regenerative Medicine
    • Dental Tissue Engineering

    Background:

    • Microspheres are versatile carriers in biomedical applications.
    • They are increasingly recognized as injectable scaffolds in regenerative medicine.
    • Their properties mimic the 3D native environment, ideal for complex anatomies.

    Purpose of the Study:

    • To summarize microsphere properties and characteristics for tissue engineering.
    • To emphasize the advantages and applications of microspheres in endodontic regeneration.
    • To highlight the role of microspheres in delivering biologics for stem cell regulation and controlled release.

    Main Methods:

    • Review of literature on microsphere scaffolds in tissue engineering.
    • Analysis of microsphere characteristics relevant to endodontic regeneration.
    • Focus on cell-laden microspheres (microcarriers and microcapsules) for dental pulp regeneration.

    Main Results:

    • Microspheres offer advantages like small size, large surface area, and 3D environment mimicry.
    • They can conform to irregular tooth anatomy, serving as ideal scaffolds for endodontic regeneration.
    • Microspheres effectively carry cells, biomolecules, and drugs to regulate stem cell fate and control release.

    Conclusions:

    • Microsphere scaffolds are highly suitable for endodontic regeneration.
    • Cell-laden microspheres demonstrate significant potential for dental pulp regeneration.
    • This review underscores the importance of microspheres in advancing tissue engineering for dental applications.