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When Poly(A) Binding Proteins Meet Viral Infections, Including SARS-CoV-2
Jie Gao1, Yan-Dong Tang2, Wei Hu1,3
1The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia Universitygrid.411643.5, Hohhot, China.
Journal of Virology
|March 16, 2022
Summary
Viruses manipulate poly(A) binding proteins (PABPs) to control gene expression for replication. This review details how viruses exploit PABPs to evade host defenses and promote viral protein synthesis.
Area of Science:
- Molecular Biology
- Virology
- Cellular Biology
Background:
- Poly(A) binding proteins (PABPs) are crucial for mRNA metabolism and translation.
- Viruses frequently target PABPs to facilitate their replication cycle.
- PABPs play multifaceted roles in both host gene regulation and viral infection processes.
Purpose of the Study:
- To comprehensively review the diverse roles of PABPs during viral infections.
- To elucidate the mechanisms by which viruses manipulate PABPs.
- To understand how viral exploitation of PABPs aids in evading host antiviral responses.
Main Methods:
- Literature review of studies on PABPs and viral interactions.
- Analysis of viral strategies targeting PABP function, stability, and localization.
- Synthesis of current knowledge on PABP manipulation in the context of viral replication.
Main Results:
- Viruses modify PABP stability, complex formation, and subcellular localization.
- Viral manipulation of PABPs promotes viral mRNA translation.
- Host protein synthesis is often suppressed or outcompeted by viral strategies involving PABPs.
Conclusions:
- PABPs are central players in the interplay between viruses and host cells.
- Understanding PABP manipulation provides insights into viral pathogenesis and host defense evasion.
- Targeting PABP-virus interactions could offer novel antiviral strategies.
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