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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Myocardial performance index increases at long-term follow-up in patients with mild to moderate COVID-19

Isa Ardahanli1, Onur Akhan2, Ebru Sahin2

  • 1Department of Cardiology, Seyh Edebali University Faculty of Medicine, Bilecik, Turkey.

Echocardiography (Mount Kisco, N.Y.)
|March 16, 2022
PubMed

Insights

Long COVID may cause lasting cardiac dysfunction, even in mild cases. Myocardial performance index (MPI) revealed left ventricular issues in survivors, suggesting its importance in cardiac assessment.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Long-term cardiovascular effects of COVID-19 remain unclear.
  • Myocardial performance index (MPI) assesses cardiac function non-invasively.
  • Unexplained cardiac symptoms post-COVID-19 warrant investigation.

Purpose of the Study:

  • Compare MPI in mild/moderate COVID-19 survivors with unexplained cardiac symptoms to a healthy control group.
  • Evaluate long-term systolic and diastolic cardiac functions post-COVID-19.

Main Methods:

  • Included 200 COVID-19 patients (mild/moderate, symptoms >2 months post-infection) and 182 healthy controls.
  • Performed echocardiographic examination, measuring isovolumetric contraction time (IVCT), isovolumetric relaxation time (IVRT), and ejection time (ET).
  • Calculated MPI using the formula: (IVCT + IVRT) / ET.

Main Results:

  • COVID-19 survivors showed significantly higher MPI (0.50 ± 0.11 vs. 0.46 ± 0.07).
  • Increased IVRT (69.67 ± 15.43 ms vs. 65.94 ± 12.03 ms) and shorter ET (271.09 ± 36.61 ms vs. 271.09 ± 36.61 ms) were observed in patients.
  • Conventional diastolic function parameters remained similar between groups.

Conclusions:

  • Mild COVID-19 survivors with long-term cardiac symptoms may have subclinical left ventricular dysfunction.
  • MPI is a sensitive indicator of cardiac involvement post-COVID-19, even when conventional parameters are normal.
  • MPI measurement is recommended for assessing cardiac function in COVID-19 survivors with persistent symptoms.
Abstract

Keywords:
COVID-19SARS-CoV2diastolic dysfunctionmyocardial performance index

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