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Updated: Sep 30, 2025

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro
Published on: November 30, 2022
Curvature effects in charge-regulated lipid bilayers
Petch Khunpetch1, Arghya Majee2,3, Rudolf Podgornik1,4,5,6,7,8
1School of Physical Sciences, University of Chinese Academy of Sciences, Beijing, China. petch@ucas.ac.cn.
Abstract:
We formulate a theory of electrostatic interactions in lipid bilayer membranes where both monolayer leaflets contain dissociable moieties that are subject to charge regulation. We specifically investigate the coupling between membrane curvature and charge regulation of a lipid bilayer vesicle using both the linear Debye-Hückel (DH) and the non-linear Poisson-Boltzmann (PB) theory. We find that charge regulation of an otherwise symmetric bilayer membrane can induce charge symmetry breaking, non-linear flexoelectricity and anomalous curvature dependence of free energy. The pH effects investigated go beyond the paradigm of electrostatic renormalization of the mechano-elastic properties of membranes.
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