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Related Experiment Videos

Infectious crystalline keratopathy.

G R Reiss, R J Campbell, W M Bourne

    Survey of Ophthalmology
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Infectious crystalline keratopathy (ICK) is a rare corneal infection causing crystalline opacities, often mistaken for sterile infiltrates. Prompt antibiotic treatment and steroid cessation are crucial for managing this condition.

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    Area of Science:

    • Ophthalmology
    • Microbiology
    • Pathology

    Background:

    • Corneal transplantation is a common procedure to restore vision.
    • Long-term topical steroid use can predispose corneas to infections.
    • Unusual corneal opacities require thorough investigation to determine etiology.

    Observation:

    • A 57-year-old female presented with crystalline-like opacities in a failing corneal graft.
    • The opacities were intrastromal and lacked significant inflammatory cells.
    • Cultures identified Streptococcus viridans as the causative agent.

    Findings:

    • Histopathology revealed intrastromal pockets of basophilic material.
    • Gram stain confirmed the material to be gram-positive bacteria.
    • Transmission electron microscopy verified intrastromal bacterial pockets, consistent with infectious crystalline keratopathy.

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    Implications:

    • Infectious crystalline keratopathy (ICK) can mimic sterile infiltrates, delaying diagnosis.
    • Management involves discontinuing topical steroids and initiating antibiotic therapy.
    • Prompt diagnosis and treatment are essential to prevent graft failure, scarring, or recurrence.