Down-regulated surfactant protein B in obese asthmatics
Thi Bich Tra Cao1, Ji-Young Moon1, Hyun-Ju Yoo2
1Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Summary
Obesity is linked to lower surfactant protein B (SP-B) levels in asthmatics, potentially impairing airway inflammation resolution. This suggests SP-B dysfunction contributes to obese asthma phenotypes.
Area of Science:
- Pulmonary Medicine
- Immunology
- Metabolic Disorders
Background:
- Obesity is a common comorbidity in adult asthma, exacerbating disease severity.
- The precise molecular mechanisms linking obesity to asthma inflammation remain unclear.
- Hydrophobic surfactant protein B (SP-B) plays a critical role in lung function.
Purpose of the Study:
- To investigate the association between circulating SP-B levels and obesity in adult asthmatics.
- To explore the role of SP-B in obesity-induced airway inflammation in asthma.
Main Methods:
- 129 adult asthmatics were categorized into obese, overweight, and normal-weight groups based on BMI.
- Circulating SP-B levels were quantified using enzyme-linked immunosorbent assay.
- Serum ceramide levels and SFTPB gene polymorphisms were analyzed.
Main Results:
- Obese asthmatics exhibited significantly lower serum SP-B levels compared to overweight and normal-weight individuals.
- Serum SP-B levels inversely correlated with BMI, C18:0 ceramide, and transforming growth factor beta 1.
- An inverse correlation between SP-B and fractional exhaled nitric oxide was observed in female asthmatics.
Conclusions:
- Obesity disrupts ceramide metabolism, leading to pulmonary surfactant dysfunction.
- Impaired surfactant function contributes to the poor resolution of airway inflammation in obese asthmatics.
- These findings elucidate key mechanisms underlying the phenotypes of obese asthmatics.
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