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Cardiac morbidity & mortality in patients with breast cancer: A review

Aruna Alahari Dhir1, Sheela Prashant Sawant1

  • 1Department of Medicine, Tata Memorial Hospital, Mumbai, Maharashtra, India.

The Indian Journal of Medical Research
|March 17, 2022
PubMed

Insights

Breast cancer survivors face higher risks of cardiovascular disease (CVD) mortality due to shared risk factors and cardiotoxic cancer treatments. Managing CVD is crucial for improving long-term survival and quality of life.

Area of Science:

  • Oncology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) and breast cancer are leading causes of morbidity and mortality in women.
  • Breast cancer survivors exhibit increased risk for CVD-related mortality.
  • Shared risk factors contribute to the co-occurrence of these conditions.

Purpose of the Study:

  • To highlight the significant public health concern of CVD in breast cancer patients.
  • To emphasize the cardiotoxic potential of breast cancer treatments.
  • To underscore the importance of assessing and managing CVD in breast cancer survivors.

Main Methods:

  • Review of existing literature on breast cancer treatment and cardiovascular complications.
  • Analysis of shared risk factors between breast cancer and CVD.
  • Examination of cardiotoxicity associated with chemotherapy, targeted therapy, and radiation.

Main Results:

  • Breast cancer survivors have a demonstrably higher risk of CVD mortality.
  • Common risk factors link breast cancer and cardiovascular diseases.
  • Cancer therapies, including anthracyclines and radiation, can induce cardiotoxicity.

Conclusions:

  • Improved breast cancer survival necessitates a focus on long-term treatment effects, particularly cardiovascular health.
  • Proactive assessment and mitigation of CVD complications are essential components of breast cancer care.
  • Managing cardiovascular risks is vital for enhancing the quality of life for breast cancer survivors.

Keywords:
Breast cancercardio-oncologycardiotoxicitycardiovascular diseases

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