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SOCS-1 1478 CA/del gene polymorphism affects survival in colorectal carcinoma
T Ayyildiz1, E Dolar2, B Oral3
1Department of Gastroenterology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Nigerian Journal of Clinical Practice
|March 17, 2022
Summary
The SOCS1 -1478CA/del gene polymorphism is not linked to colorectal cancer (CRC) development. However, the del/del allele is associated with poorer overall survival and progression-free survival in CRC patients.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Suppressor of cytokine signaling 1 (SOCS1) is a key molecule in the SOCS family.
- Altered SOCS1 expression is observed in human cancers, suggesting a potential tumor suppressor role.
- SOCS1 gene polymorphisms may influence cancer development and progression.
Purpose of the Study:
- To investigate the association between the SOCS1 promoter -1478CA/del gene polymorphism and colorectal cancer (CRC).
- To evaluate the relationship between this polymorphism and histopathological characteristics in CRC patients.
- To determine the impact of the SOCS1 polymorphism on patient survival outcomes.
Main Methods:
- Retrospective study involving 53 CRC patients and 23 controls.
- SOCS1 -1478CA/del gene polymorphism analyzed using polymerase chain reaction-restriction fragment length polymorphism.
- Statistical analysis of polymorphism data against histopathological features and survival.
Main Results:
- No significant association found between SOCS1 -1478CA/del polymorphism and CRC development (p=0.248).
- The polymorphism did not correlate with histopathological features of CRC.
- Patients with the del/del allele exhibited a 3.9-fold increased mortality risk (p=0.05) and significantly shorter progression-free survival (PFS) and overall survival (OS) (p=0.05).
Conclusions:
- The SOCS1 -1478CA/del gene polymorphism is not a risk factor for CRC development.
- CRC patients with the del/del allele demonstrate significantly poorer PFS and OS compared to those with CA/CA or CA/del alleles.
- This polymorphism may serve as a prognostic marker for survival in colorectal cancer.
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