Correlation of Cardiovascular Risk Parameters with Serum IL.6 and C-RP in Myocardial Infarction

Area of Science:

• Cardiology
• Biochemistry
• Inflammation Research

Background:

• Acute myocardial infarction (AMI) is a leading cause of mortality worldwide.
• Inflammatory markers like interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) are implicated in cardiovascular disease pathogenesis.
• Understanding the relationship between these markers and traditional cardiovascular risk factors is crucial for risk stratification and management.

Purpose of the Study:

• To investigate the correlation between serum IL-6 and hs-CRP levels and various cardiovascular risk parameters in patients with AMI.
• To compare these inflammatory markers in AMI patients versus healthy controls.

Main Methods:

• Blood samples were collected from 100 AMI patients and 40 age- and BMI-matched healthy controls.
• Serum levels of IL-6 and hs-CRP were measured.
• Cardiovascular risk parameters including fasting plasma glucose, HbA1c, triglycerides, LDLc, HDLc, BMI, and waist circumference were assessed.

Main Results:

• AMI patients exhibited significantly higher median IL-6 and hs-CRP levels compared to controls (P < 0.001).
• Elevated fasting plasma glucose, HbA1c, triglycerides, and LDLc, along with lower HDLc, were observed in the AMI group.
• While hs-CRP correlated with BMI and waist circumference in AMI patients, neither IL-6 nor hs-CRP showed significant correlations with other biochemical cardiovascular risk parameters.

Conclusions:

• IL-6 and hs-CRP are significantly elevated in patients with AMI.
• Despite elevated levels, IL-6 and hs-CRP did not demonstrate significant correlations with common biochemical cardiovascular risk parameters in this AMI cohort.
• Further research is warranted to elucidate the precise role of IL-6 and hs-CRP in AMI pathogenesis.