Related Experiment Video
Updated: Sep 30, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Biased Opioid Ligands: Revolution or Evolution?
Florence Noble1, Nicolas Marie1
1Université de Paris, CNRS ERL 3649 Pharmacologie et thérapies des addictions, Inserm UMR-S 1124 T3S Environmental Toxicity, Therapeutic Targets Cellular Signaling and Biomarkers, Paris, France.
Abstract:
Opioid are the most powerful analgesics ever but their use is still limited by deleterious side effects such as tolerance, dependence, and respiratory depression that could eventually lead to a fatal overdose. The opioid crisis, mainly occurring in north America, stimulates research on finding new opioid ligands with reduced side effects. Among them, biased ligands are likely the most promising compounds. We will review some of the latest discovered biased opioid ligands and see if they were able to fulfill these expectations.
Related Concept Videos
Opioid Receptors: Overview
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Analgesia and Pain Management
Opioid Analgesics: Morphine and Other Natural Cogeners
Drug-Receptor Interaction: Agonist
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
Ligand-Gated Ion Channel Receptor: Gating Mechanism

