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Updated: Sep 30, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Published on: October 4, 2019

Antimicrobial Diterpenes: Recent Development From Natural Sources.

Poushali Saha¹, Fahad Imtiaz Rahman¹, Fahad Hussain²

¹Faculty of Pharmacy, Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

Frontiers in Pharmacology

|March 17, 2022

Summary

Natural diterpenoids show potent antimicrobial activity against various pathogens, offering a promising alternative to ineffective antibiotics. This review highlights their potential for developing new antimicrobial agents to combat resistance.

Keywords:

antibacterial activity antifungal activity antimicrobial resistance antiprotozoal activity antiviral activity diterpenes diterpenoids

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Published on: January 13, 2017

Area of Science:

Natural product chemistry
Microbiology
Drug discovery

Background:

Antimicrobial resistance (AMR) is a growing global health threat.
Existing antibiotics are becoming less effective, necessitating the search for novel antimicrobial compounds.
Natural products, particularly secondary metabolites, are a rich source of potential new drugs.

Purpose of the Study:

To systematically review recent literature on natural diterpenoids with antimicrobial properties.
To summarize their chemical structures, classification, and antimicrobial activities (antibacterial, antifungal, antiviral, antiprotozoal).
To analyze reported structure-activity relationships (SAR) and mechanisms of action.

Main Methods:

Systematic literature review following PRISMA guidelines.
Focus on research published within the last five years.
Compilation and summarization of data on 229 diterpenoids from diverse natural sources.

Main Results:

Identified 229 diterpenoids from plants, marine organisms, and fungi with significant antimicrobial activities.
Detailed their chemical structures, classifications, and mechanisms of action.
Summarized SAR data, providing insights into molecular features contributing to efficacy.

Conclusions:

Natural diterpenoids represent a valuable resource for developing new antimicrobial agents.
Understanding their SAR can guide the design of synthetic and semi-synthetic derivatives.
Further research into these compounds may yield novel treatments for infectious diseases.