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Statin Use in Hospitalized Patients with COVID-19: A Comprehensive Analysis of the New York City Public Hospital
Weijia Li1, Saul Rios1, Sanjana Nagraj1
1Department of Medicine, New York City Health + Hospitals/Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Insights
Statins may reduce mortality and the need for mechanical ventilation in hospitalized COVID-19 patients. This study found lower in-hospital death rates for patients taking statins during their illness.
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- Statins are widely used for cardiovascular prevention.
- Statins possess anti-inflammatory properties.
- The impact of statins on COVID-19 outcomes is under investigation.
Purpose of the Study:
- To investigate the association between statin use and in-hospital outcomes in patients hospitalized with COVID-19.
- To determine if statins improve survival and reduce the need for mechanical ventilation in COVID-19 patients.
Main Methods:
- Retrospective study of 8897 adult patients hospitalized with COVID-19.
- Propensity score matching to compare statin and non-statin groups.
- Multivariate logistic regression to analyze in-hospital mortality and mechanical ventilation.
Main Results:
- After matching, 2817 patients were in each group (statin vs. non-statin).
- Statin use was associated with a significantly lower risk of in-hospital mortality (OR 0.71).
- Statin use was also linked to a reduced need for mechanical ventilation (OR 0.80).
Conclusions:
- Statin use is associated with improved in-hospital outcomes for COVID-19 patients.
- Statins may reduce mortality and mechanical ventilation requirements in hospitalized COVID-19 cases.
Introduction:
Statins have been commonly used for primary and secondary cardiovascular prevention. We hypothesized that statins may improve in-hospital outcomes for hospitalized patients with Coronavirus disease 2019 (COVID-19) due to its known anti-inflammatory effects.
Methods:
We conducted a retrospective study at the largest municipal health care system in the United States, including adult patients who were hospitalized for COVID-19 between March 1 and December 1, 2020. The primary endpoint was in-hospital death. Propensity score matching was conducted to balance possible confounding variables between patients receiving statins during hospitalization (statin group) and those not receiving statins (non-statin group). Multivariate logistic regression was used to evaluate the association of statin use and other variables with in-hospital outcomes.
Results:
There were 8897 patients eligible for study enrollment, with 3359 patients in the statin group and 5538 patients in the non-statin group. After propensity score matching, both the statin and non-statin groups included 2817 patients. Multivariate logistic regression analysis showed that the statin group had a significantly lower risk of in-hospital mortality (odds ratio 0.71; 95% confidence interval, 0.63-0.80; P < .001) and mechanical ventilation (OR 0.80; 95% confidence interval, 0.71-0.90; P < .001) compared with the non-statin group.
Conclusion:
Statin use was associated with lower likelihood of in-hospital mortality and invasive mechanical ventilation in hospitalized patients with COVID-19.