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Nanomaterial-based aptamer biosensors for ochratoxin A detection: a review
Xiujin Chen1, Dong Gao1, Fengxia Sun2
1College of Food and Bioengineering, National Demonstration Center for Experimental Food Processing and Safety Education, Engineering Center of Food Material, Henan University of Science and Technology, NO. 263 Kaiyuan Avenue, Luolong District, Luoyang, 471000, Henan, China.
Abstract:
Ochratoxin A (OTA) is a widely distributed mycotoxin that often contaminates food, grains and animal feed. It poses a serious threat to human health because of its high toxicity and persistence. Therefore, the development of an inexpensive, highly sensitive, accurate and rapid method for OTA detection is imperative. In recent years, various nanomaterials used in the establishment of aptasensors have attracted great attention due to their large surface-to-volume ratio, good stability and facile preparation. This review summarizes the development of nanomaterial-based aptasensors for OTA determination and sample treatment over the past 5 years. The nanomaterials used in OTA aptasensors include metal, carbon, luminescent, magnetic and other nanomaterials. Finally, the limitations and future challenges in the development of nanomaterial-based OTA aptasensors are reviewed and discussed.
