Age-associated B cells in viral infection

Area of Science:

• Immunology
• Virology
• Cell Biology

Background:

• Age-associated B cells (ABCs) are a distinct B cell subset with dual protective and pathogenic roles.
• ABCs are increasingly recognized for their significant involvement in immune responses.

Purpose of the Study:

• To review the current understanding of ABCs in antiviral responses in humans and mice.
• To highlight knowledge gaps and future research directions concerning ABCs.

Main Methods:

• Literature review of studies investigating ABCs in viral infections.
• Analysis of ABC functional capacities, including antibody secretion and T cell activation.

Main Results:

• ABCs expand during viral infections and exhibit diverse functional capabilities.
• ABCs persist post-infection, contributing to immunological memory and recall responses.

Conclusions:

• ABCs play a critical role in the antiviral immune response.
• Future research should explore the impact of sex and context-specific heterogeneity on ABC populations and functions.