Related Experiment Video
Updated: Sep 30, 2025
Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
Published on: January 12, 2017
Effect of Supervised Resistance Training on Arm Volume, Quality of Life and Physical Perfomance Among Women at High
Karol Ramírez-Parada1, Maria Lopez-Garzon2,3,4, Cesar Sanchez-Rojel5
1Carrera de Kinesiología, Departamento Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Objectives:
To determine the preventive effects of supervised resistance training on arms volume, quality of life, physical performance, and handgrip strength in Chilean women at high risk for breast cancer-related lymphedema (BCRL) undergoing chemotherapy.
Design:
Randomized control trial.
Participants:
One hundred and six women at high risk for breast cancer-related lymphedema aged 18 to 70 years.
Interventions:
Participants will be randomized into two groups: [a] intervention, who will receive 12 weeks of supervised resistance training (STRONG-B) during adjuvant chemotherapy; and [b] control, who will receive education to promote lymphatic and venous return, maintain range of motion, and promote physical activity.
Main Outcome Measures:
The primary outcome will be arms volume measured with an optoelectric device (perometer NT1000). Secondary outcomes will be quality of life, handgrip strength, and physical performance. Primary and secondary outcomes will be measured at baseline, just after the intervention, and 3 and 6 months after. Statistical analysis will be performed following intention-to-treat and per-protocol approaches. The treatment effect will be calculated using linear mixed models.
Discussion:
The STRONG-B will be a tailored supervised resistance training that attempts to prevent or mitigate BCRL in a population that, due to both intrinsic and extrinsic factors, will commonly suffer from BCRL.
Clinical Trial Registration:
[https://clinicaltrials.gov/ct2/show/NCT04821609], identifier NCT04821609.
