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Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
Listeria Monocytogenes Meningitis in an Immunocompetent Patient
Oana Magiar1, Silvana Vulpie1,2, Corina Musuroi1,3
1Clinical Laboratory, "Pius Brînzeu" County Clinical Emergency Hospital Timisoara, Timis, Romania.
Abstract:
Listeria monocytogenes (LM), one of the most important foodborne pathogens, is an intracellular bacterium found in food and the environment. It causes listeriosis, a potentially severe disease, particularly for pregnant women, the elderly and immunocompromised patients, but in rare cases, it can cause invasive disease in immunocompetent adults and children. Community-acquired bacterial meningitis caused by LM is rare and difficult to diagnose. It carries a high mortality rate; therefore, it is essential to start appropriate antibiotic treatment as soon as possible. The first case of LM meningitis identified in our hospital over the last 10 years is that of a previously healthy 45-year-old man who presented in the emergency department with a 4-day history of diplopia, left eye medial deviation and left palpebral ptosis, with no history of fever, headache or gastrointestinal symptoms. Because of the atypical symptoms, a suspicion of meningitis vs cerebral aneurysm was raised during the admission process. The patient was diagnosed with LM meningitis and recovered fully after appropriate antibiotic treatment. The purpose of this article is to emphasise the possibility of LM invasive disease (in this case meningitis) occurring in previously healthy individuals and to raise awareness about the need for LM to be considered in the differential diagnosis of atypical presentations.
Insights
Listeria monocytogenes (LM) can cause severe meningitis, even in healthy individuals. Early diagnosis and antibiotic treatment are crucial for recovery from this rare but dangerous foodborne illness.
Area of Science:
- Infectious Diseases
- Bacteriology
- Neurology
Background:
- Listeria monocytogenes (LM) is a significant foodborne pathogen causing listeriosis, a severe illness particularly in vulnerable populations.
- LM meningitis is a rare complication, challenging to diagnose and associated with high mortality.
- Prompt antibiotic intervention is critical for managing LM infections.
Observation:
- A previously healthy 45-year-old man presented with atypical neurological symptoms including diplopia and ptosis, without typical meningitis signs.
- Initial differential diagnosis considered meningitis versus cerebral aneurysm due to the unusual presentation.
- The patient was diagnosed with Listeria monocytogenes meningitis.
Findings:
- The patient fully recovered following appropriate antibiotic therapy for LM meningitis.
- This case highlights that invasive LM disease, such as meningitis, can occur in immunocompetent adults.
- Atypical presentations of LM meningitis underscore diagnostic challenges.
Implications:
- Clinicians should consider Listeria monocytogenes in the differential diagnosis of meningitis, especially with atypical neurological symptoms.
- Increased awareness of LM's potential to cause invasive disease in healthy individuals is necessary.
- Early recognition and treatment of LM meningitis can improve patient outcomes.

