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Updated: Sep 30, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
Published on: August 12, 2015
BRCA1 and Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
Xiaoyu Fu1,2, Wei Tan3, Qibin Song2
1Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
Abstract:
Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is mainly involved in the repair of DNA damage, cell cycle regulation, maintenance of genome stability, and other important physiological processes. Mutations or defects in the BRCA1 gene significantly increase the risk of breast, ovarian, prostate, and other cancers in carriers. In this review, we summarized the molecular functions and regulation of BRCA1 and discussed recent insights into the detection and treatment of BRCA1 mutated breast cancer.
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