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Updated: Sep 30, 2025
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
Published on: August 15, 2022
Donation after circulatory death donors in high-risk recipients undergoing bilateral lung transplantation: An ISHLT
Pedro Augusto Reck Dos Santos1, Paulo José Zimermann Teixeira2, Daniel Messias de Moraes Neto3
1Department of Cardiothoracic Surgery, Mayo Clinic, Phoenix, Arizona; Programa de Pós-Graduação em Ciências da Saúde - Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Abstract:
Lung transplantation (LTx) using donation after circulatory death (DCD) donors has demonstrated equivalent outcomes compared to donation after brain dead (DBD) donors. However, data from the use of DCDs for high-risk (HR) recipients is limited. We performed a propensity match study to evaluate the impact of DCD transplantation on HR recipients. In addition, we assessed the effect of recipient profile (HR vs. non-HR) in DCDs and DBDs LTx. From 2009-2018, 1829 double lung transplants (DLTx) for HR recipients were identified. Of these, 131 were performed using DCD donors. There was no difference in survival between DCDs and DBDs among HR-DLTx recipients (p = 0.16). However, HR recipients had worse survival compared to non-HR recipients in DBD (p < 0.001) but not in DCD transplantation (p = 0.95). Our findings support that DCD lungs are appropriate for HR recipients and should not be considered inferior or higher-risk donors. Its use should be further stimulated rather than restricted.
