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In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
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Genetically modified rabbit models for cardiovascular medicine.

Ying Hou1, Xin Zhang1, Xia Sun2

  • 1Institute of Basic and Translational Medicine, Shaanxi Key Laboratory of Brain Disorders, Xi'an Medical University, Xi'an, Shaanxi, 710021, China.

European Journal of Pharmacology
|March 18, 2022
PubMed
Summary

Genetically modified rabbits are crucial models for human diseases, especially cardiovascular conditions. Recent advances in gene editing technologies like CRISPR have significantly improved genetic modification techniques in rabbits.

Keywords:
Animal modelCardiovascular medicineGene targetingGenetically modified rabbit

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Area of Science:

  • Animal models
  • Genetic engineering
  • Cardiovascular medicine

Background:

  • Genetically modified (GM) rabbits serve as vital models for human diseases.
  • GM rabbits expressing human genes are extensively used for cardiovascular disease research.
  • Traditional gene modification in rabbits involves random gene integration, limiting precise gene targeting.

Purpose of the Study:

  • To review recent advancements in genetically modified rabbit technology.
  • To highlight the application of GM rabbits in cardiovascular medicine.
  • To discuss the evolution of gene targeting techniques in rabbits.

Main Methods:

  • Review of scientific literature on rabbit genetic modification.
  • Discussion of prokaryotic microinjection and RNA interference techniques.
  • Analysis of novel gene editing tools: zinc-finger nucleases (ZFNs), TALENs, CRISPR, and CRISPR/Cas9.

Main Results:

  • Gene targeting in rabbits has been historically challenging due to the lack of stable embryonic stem cell lines.
  • RNA interference offers a method for gene knockdown and modification.
  • Emerging technologies like ZFNs, TALENs, and CRISPR/Cas9 have enabled successful gene targeting and the creation of knockout rabbit models.

Conclusions:

  • Recent breakthroughs in gene editing technologies have revolutionized rabbit genetic modification.
  • These advanced techniques facilitate the development of more precise animal models for studying human diseases.
  • Genetically modified rabbits are increasingly valuable for cardiovascular research and drug development.