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Hypoxia responsive phytonanotheranostics: A novel paradigm towards fighting cancer
Sarbari Acharya1, Ranjita Misra2
1School of Applied Sciences, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha, India.
Nanomedicine : Nanotechnology, Biology, and Medicine
|March 18, 2022
Summary
Phytomedicine incorporated into nanoparticles offers a new approach for hypoxia therapy in cancer. This review explores smart phytonanotheranostics for targeted cancer treatment and monitoring in hypoxic environments.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Hypoxia significantly increases tumor aggressiveness and reduces anticancer therapy effectiveness.
- Phytomedicine, despite its therapeutic potential, faces limitations in conventional delivery.
- Nanoparticle-based drug delivery systems offer a promising avenue for overcoming these challenges.
Purpose of the Study:
- To review the development and application of smart stimuli-responsive phytonanotherapeutics for hypoxia-driven cancer.
- To highlight the potential of phytonanomedicine and phytonanotheranostics in managing hypoxic tumors.
- To identify research gaps and encourage future studies in this emerging field.
Main Methods:
- Literature review focusing on stimuli-responsive nanoparticles, phytomedicine, and hypoxia.
- Analysis of current research on phytonanomedicine and phytonanotheranostics for cancer therapy.
- Synthesis of information on smart nanotheranostics tailored for the tumor microenvironment.
Main Results:
- Phytonanomedicine and phytonanotheranostics show potential for targeted drug delivery and improved cancer management in hypoxic conditions.
- Smart nanoparticles offer controlled, on-demand drug release based on internal or external stimuli.
- Limited studies currently exist on tailor-made nanotheranostics within the hypoxic tumor microenvironment.
Conclusions:
- Smart stimuli-responsive phytonanotherapeutics represent a novel strategy for enhancing cancer treatment efficacy in hypoxic tumors.
- Further research is needed to fully explore the potential of these advanced nanomedicines.
- This review consolidates current knowledge to guide future investigations in phytonanotheranostics for oncology.
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