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Updated: Sep 29, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

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[Case report: persistent fever after SARS-CoV-2 infection].

T Kliem¹, D Strobel², F Heinke²

¹Medizinische Klinik 1, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland. thorsten.kliem@uk-erlangen.de.

Innere Medizin (Heidelberg, Germany)

|March 18, 2022

Summary

A severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection can lead to subacute granulomatous thyroiditis. Prompt prednisolone treatment effectively managed the hyperthyroidism and resolved symptoms.

Keywords:

COVID-19 De Quervain’s thyroiditis Diagnostic ultrasound Subacute granulomatous thyroiditis Tachycardia

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Area of Science:

Endocrinology
Infectious Diseases
Internal Medicine

Background:

Persistent fever and tachycardia can indicate underlying endocrine or infectious complications post-viral illness.
Subacute granulomatous thyroiditis is an inflammatory condition of the thyroid gland, often triggered by viral infections.

Observation:

A 44-year-old male presented with persistent fever after a SARS-CoV-2 infection.
Progressive sinus tachycardia prompted thyroid hormone level assessment, revealing hyperthyroidism.
Thyroid sonography showed thyroid gland enlargement with hypoechoic areas and blurred margins.

Findings:

The patient was diagnosed with subacute granulomatous thyroiditis linked to SARS-CoV-2 infection.
Treatment with prednisolone was initiated for the diagnosed thyroiditis.
The patient experienced rapid clinical improvement and complete remission within three months.

Implications:

This case highlights a potential, albeit rare, endocrine complication of SARS-CoV-2 infection.
Early diagnosis and corticosteroid therapy are crucial for managing SARS-CoV-2-associated thyroiditis.
Further research is warranted to understand the immunopathogenesis of post-COVID-19 thyroiditis.